Everyone is different so it is unknown what will work best for you. Skin damage is primarily due to uncontrolled moisture but can also occur from excessive compression and extended compression on the same spot. If, and when irritation of the areas contacted occurs - reduce the amount of compression and reposition the clamp to avoid the area. Some users recommend using baby powder frequently. For sores or irritation users recommend a liberal coat on a zinc based ointment such as Calmoseptine Ointment or Balmex Adult Care Rash Cream . If for any reason you notice restricted blood flow, a rash, swelling, or tissue damage, or the device cannot be adjusted to be comfortable discontinue use and consult your physician. If the device breaks or is damaged replace. Dispose of properly. Cleanliness and skin protectant are very important. Use a Perineal Wash No-Rinse Cleanser like McKesson combined with a preferred barrier cream skin protectant with dimethicone such as HealthPoint Proshield Plus, Cavilon Durable Barrier Cream, Inzo Smooth and Cool, or Baza Protect Moisture Barrier Cream Products containing Petrolatum/Vaseline will work but it can damage some plastics such as the nylon that this device is made of. Lanolin based ointments may also work but there are some versions are reported to cause irritation.